Opportunity Information: Apply for PD 22 7334
The National Science Foundation (NSF) Mathematical Biology Program (Funding Opportunity Number PD 22-7334) funds research grants that sit at the intersection of applied or computational mathematics and the biological sciences. The core expectation is that proposed work is not just "math applied to biology" or "biology with some modeling," but a tightly integrated project where the mathematical ideas and the biological questions genuinely drive each other. Competitive proposals are expected to show clear mathematical innovation (new theory, new methods, or a meaningful advance in existing mathematical frameworks), strong biological relevance and significance (a real biological problem with clear importance), and a convincing plan for integration between the two disciplines.
The program is broad in the kinds of mathematical approaches it welcomes, including areas that may traditionally be housed elsewhere within NSF's Division of Mathematical Sciences. Examples explicitly noted include topology, probability, statistics, and computational mathematics, among others, as long as the work is meaningfully connected to biological science and the proposal makes the case for why these tools are needed and what new insight they enable. Because many projects naturally overlap multiple NSF programs, investigators are encouraged to communicate early with the relevant program officers. If a project could reasonably be reviewed by more than one program, NSF recommends contacting the program officers for each potentially relevant program to decide where to submit and to help coordinate the review process. The Mathematical Biology Program also regularly pursues joint reviews with programs in the Biological Sciences and Engineering directorates, which can be helpful for proposals that genuinely span disciplinary boundaries.
The opportunity is listed as a discretionary grant in the Science and Technology and other Research and Development category (CFDA 47.049). Eligibility is described as unrestricted, meaning it is broadly open to different entity types, subject to any specific eligibility clarifications that may appear in the full solicitation or related NSF policy documents. Proposals are accepted on an ongoing basis (no single deadline listed), and NSF anticipates making around 30 awards. The award ceiling is shown as 0, which typically signals that a fixed maximum is not specified in the listing itself; applicants generally need to rely on NSF guidance, norms for the program, and conversations with program staff to shape an appropriate budget.
The description also highlights several submission pathways and special cases that come with extra requirements. Faculty at Research in Undergraduate Institutions (RUI) can apply, but they are expected to follow the separate RUI solicitation because formatting and preparation rules can differ from the standard NSF Proposal and Award Policies and Procedures Guide (PAPPG). For EAGER (early concept, exploratory) and RAPID (rapid response) proposals, prior contact with the cognizant program directors is required before submission, reflecting NSF's normal practice that these mechanisms need advance discussion and approval. Similarly, principal investigators considering requests for award supplements are encouraged to contact the program director before submitting the supplement request, and to consult the PAPPG for procedural details.
Finally, the program notes conference and workshop support as another activity area, with a reminder to consult the NSF solicitation "Conferences and Workshops in the Mathematical Sciences" for specific content expectations. Timing matters for these proposals: events held in the United States should be proposed about 8 months in advance, while requests to support group travel to meetings outside the United States should be submitted about 12 months ahead of the meeting date. Overall, the opportunity is designed for researchers who can demonstrate both cutting-edge mathematical development and a clear, high-impact biological application, and who are willing to coordinate across NSF programs when the project spans multiple review communities.Apply for PD 22 7334
- The National Science Foundation in the science and technology and other research and development sector is offering a public funding opportunity titled "Mathematical Biology" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 47.049.
- This funding opportunity was created on Jul 11, 2022.
- Applicants must submit their applications by Proposals accepted anytime. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 30 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQs): NSF Mathematical Biology Program (PD 22-7334)
1) What is the NSF Mathematical Biology Program (PD 22-7334)?
The NSF Mathematical Biology Program supports research grants at the intersection of applied or computational mathematics and the biological sciences. The program is aimed at projects where mathematics and biology are tightly linked, with each side shaping the other in a meaningful way.
2) What kind of projects are considered a good fit for this program?
Projects are expected to be genuinely integrative. A good fit is not simply "math applied to biology" or "biology with some modeling," but rather a project where mathematical ideas and biological questions actively drive one another. Competitive proposals typically show mathematical innovation, clear biological significance, and a convincing integration plan.
3) What does NSF mean by "tightly integrated" math-biology research?
Based on the program description, integration means the biology is not just an example problem for a mathematical method, and the math is not a minor add-on to a biological study. Instead, the biological problem should motivate the mathematical development, and the mathematical development should enable new biological insight that would be difficult to obtain otherwise.
4) What are reviewers likely to expect from a competitive proposal?
The description highlights three expectations for competitive proposals:
- Clear mathematical innovation: new theory, new methods, or a meaningful advance in an existing mathematical framework.
- Strong biological relevance and significance: a real biological problem with clear importance.
- A convincing plan for integration: an explanation of how the disciplines are linked and how they will inform each other throughout the project.
5) What mathematical areas or methods does the program welcome?
The program is broad in the types of mathematical approaches it welcomes, including approaches often housed elsewhere within NSF's Division of Mathematical Sciences. Examples explicitly noted include topology, probability, statistics, and computational mathematics, among others, as long as the proposal clearly connects the work to biological science and explains why the mathematical tools are needed and what new insight they enable.
6) Is it acceptable if my project overlaps multiple NSF programs?
Yes. The program description explicitly recognizes that many projects overlap multiple NSF programs. Investigators are encouraged to communicate early with relevant program officers, especially if a proposal could reasonably be reviewed by more than one program.
7) Should I contact NSF program officers before submitting?
The description recommends early communication with program officers when a project could fit more than one program. This can help determine where to submit and can help coordinate the review process across programs.
8) Does the Mathematical Biology Program coordinate reviews with other NSF areas?
Yes. The description notes that the program regularly pursues joint reviews with programs in the Biological Sciences and Engineering directorates. This can be helpful for proposals that truly span disciplinary boundaries.
9) What is the assistance listing category and CFDA number for this opportunity?
The opportunity is listed as a discretionary grant in the Science and Technology and other Research and Development category, with CFDA 47.049.
10) Who is eligible to apply?
Eligibility is described as unrestricted, meaning it is broadly open to different entity types, subject to any specific eligibility clarifications that may appear in the full solicitation or related NSF policy documents.
11) Are there deadlines, or is this an open submission opportunity?
Proposals are accepted on an ongoing basis, with no single deadline listed in the provided information.
12) Approximately how many awards does NSF expect to make?
NSF anticipates making around 30 awards under this opportunity, based on the information provided.
13) Is there a maximum (ceiling) award amount listed?
The award ceiling is shown as 0, which typically indicates that a fixed maximum is not specified in the listing itself. Applicants generally need to rely on NSF guidance, typical program norms, and conversations with program staff to determine an appropriate budget level.
14) Do RUI (Research in Undergraduate Institutions) faculty apply through this program the same way as standard NSF proposals?
RUI faculty can apply, but they are expected to follow the separate RUI solicitation. The description notes that formatting and preparation rules can differ from the standard NSF Proposal and Award Policies and Procedures Guide (PAPPG).
15) What should RUI applicants pay special attention to?
Based on the description, RUI applicants should follow the separate RUI solicitation because proposal formatting and preparation requirements may differ from the standard PAPPG expectations.
16) Are EAGER proposals allowed, and are there special requirements?
Yes, EAGER (early concept, exploratory) proposals are mentioned as a pathway. Prior contact with the cognizant program directors is required before submission.
17) Are RAPID proposals allowed, and are there special requirements?
Yes, RAPID (rapid response) proposals are mentioned as a pathway. Prior contact with the cognizant program directors is required before submission.
18) Do I need to contact NSF before requesting an award supplement?
For requests for award supplements, the description encourages principal investigators to contact the program director before submitting the supplement request. It also advises consulting the PAPPG for procedural details.
19) Does this opportunity support conferences or workshops?
Yes. Conference and workshop support is highlighted as an activity area. The description directs applicants to consult the NSF solicitation titled "Conferences and Workshops in the Mathematical Sciences" for specific content expectations.
20) How far in advance should a U.S.-based conference or workshop be proposed?
For events held in the United States, the description recommends proposing about 8 months in advance.
21) How far in advance should international group travel support be requested?
For requests to support group travel to meetings outside the United States, the description recommends submitting about 12 months ahead of the meeting date.
22) How should applicants justify the mathematical approach in a biology-focused context?
The description indicates that proposals should make the case for why the chosen mathematical tools are needed and what new biological insight those tools enable. In other words, applicants should connect the method to the biological question and explain the added value created by the mathematics.
23) What is the overall intent of the program?
The overall intent is to support researchers who can demonstrate both cutting-edge mathematical development and a clear, high-impact biological application, and who are willing to coordinate across NSF programs when the project spans multiple review communities.
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