Opportunity Information: Apply for RFA DA 24 013
Mechanisms and Targets at the Intersection of HIV and Substance Use (R01 Clinical Trials Not Allowed) is a National Institutes of Health (NIH) discretionary grant opportunity (Funding Opportunity Number RFA-DA-24-013; CFDA 93.279) focused on basic, non-clinical-trial research that explains how HIV infection and addictive substances work together to disrupt the central nervous system (CNS). The central scientific goal is to map and understand the signaling pathways and molecular mechanisms through which HIV and drugs of abuse converge to alter brain function, drive neuropathological changes, and contribute to neurocognitive impairments. A key emphasis is on HIV-host protein interactions and post-translational modifications, meaning the FOA is looking for mechanistic studies that dig into how proteins interact and how chemical changes to proteins after they are made can reshape cellular behavior in ways that ultimately affect brain health in the context of HIV and substance use.
In addition to clarifying mechanisms, the FOA aims to push the field toward solutions by encouraging the discovery and early development of novel chemical and biological approaches that could prevent, reduce, or otherwise mitigate CNS complications linked to HIV infection and substance use disorders. In practice, this can include work that identifies new molecular targets, validates their roles in disease-relevant models, and explores candidate interventions or protective strategies at the basic research stage. While the notice is oriented toward therapeutic and preventive possibilities, it explicitly indicates that clinical trials are not allowed under this R01, so the expected work remains preclinical or mechanistic rather than testing interventions in human trial settings.
The funding mechanism is an R01 grant, and the listed award ceiling is $400,000 (as provided in the source data). The opportunity was created on 2022-12-16, and the original closing date was 2023-08-09, indicating it was tied to a specific submission window. The activity categories are Education and Health, reflecting NIHs biomedical research mission and the intersection of infectious disease, addiction science, neuroscience, and public health impact.
Eligibility is broad and spans many organization types across the public, private, nonprofit, and governmental sectors. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public housing authorities/Indian housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; and Native American tribal organizations other than federally recognized governments. The FOA also allows nonprofits with or without 501(c)(3) status (outside higher education), for-profit organizations (other than small businesses), small businesses, and other categories. It explicitly highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. (foreign) organizations, as well as Indian/Native American tribal governments that are not federally recognized. This wide eligibility reflects NIHs interest in drawing proposals from diverse research environments and communities, including those disproportionately affected by HIV and substance use-related harms.
Overall, the opportunity targets foundational neuroscience and molecular biology questions at the HIV-substance use interface, with a clear expectation that projects will illuminate how combined exposures drive brain dysfunction and will lay groundwork for new prevention or mitigation strategies for HIV-associated CNS complications in the setting of substance use disorders, without conducting clinical trials.Apply for RFA DA 24 013
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Mechanisms and Targets at the Intersection of HIV and Substance Use (R01 Clinical Trials Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on 2022-12-16.
- Applicants must submit their applications by 2023-08-09. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $400,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
FAQs: Mechanisms and Targets at the Intersection of HIV and Substance Use (R01 Clinical Trials Not Allowed)
What is the official title of this grant opportunity?
The opportunity is titled Mechanisms and Targets at the Intersection of HIV and Substance Use (R01 Clinical Trials Not Allowed).
Which agency is offering this funding opportunity?
This is a National Institutes of Health (NIH) discretionary grant opportunity.
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-DA-24-013.
What is the CFDA number listed for this opportunity?
The CFDA number provided is 93.279.
What kind of grant mechanism is being used?
The funding mechanism is an R01 research project grant.
Are clinical trials allowed under this R01?
No. The opportunity explicitly states Clinical Trials Not Allowed, so projects should be mechanistic and/or preclinical rather than testing interventions in human trial settings.
What is the central scientific focus of the FOA?
The FOA focuses on basic, non-clinical-trial research that explains how HIV infection and addictive substances work together to disrupt the central nervous system (CNS).
What is the main research goal described in the opportunity?
The central goal is to map and understand signaling pathways and molecular mechanisms through which HIV and drugs of abuse converge to alter brain function, drive neuropathological changes, and contribute to neurocognitive impairments.
What types of biological mechanisms are emphasized?
A key emphasis is on HIV-host protein interactions and post-translational modifications, meaning mechanistic studies that examine how proteins interact and how chemical changes to proteins after they are made can reshape cellular behavior in ways that affect brain health in the context of HIV and substance use.
Does the FOA only support mechanistic research, or does it also encourage solution-oriented work?
In addition to clarifying mechanisms, the FOA encourages the discovery and early development of novel chemical and biological approaches that could prevent, reduce, or mitigate CNS complications linked to HIV infection and substance use disorders, as long as the work remains non-clinical-trial in scope.
What kinds of solution-oriented activities are mentioned as fitting this FOA (without conducting clinical trials)?
The description includes work that identifies new molecular targets, validates their roles in disease-relevant models, and explores candidate interventions or protective strategies at the basic research stage.
What body system or health outcome area is most directly targeted?
The FOA targets the central nervous system (CNS), specifically how combined HIV infection and substance use can contribute to brain dysfunction, neuropathological changes, and neurocognitive impairments.
What is the award ceiling listed for this opportunity?
The listed award ceiling is $400,000 (as provided in the source data).
When was this opportunity created?
The opportunity was created on 2022-12-16.
What was the original closing date?
The original closing date provided is 2023-08-09, indicating it was tied to a specific submission window.
What activity categories are associated with this opportunity?
The activity categories listed are Education and Health.
Who is eligible to apply in general terms?
Eligibility is described as broad and includes a wide range of public, private, nonprofit, and governmental organizations, as well as U.S. and non-U.S. (foreign) organizations.
Which U.S. government entities are listed as eligible applicants?
Eligible government applicants include state governments, county governments, city or township governments, and special district governments.
Are schools and higher education institutions eligible?
Yes. Eligible applicants include independent school districts, public and state-controlled institutions of higher education, and private institutions of higher education.
Are housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are included as eligible applicants.
Are tribal entities eligible to apply?
Yes. Eligibility includes federally recognized Native American tribal governments, Native American tribal organizations other than federally recognized governments, and also explicitly includes Indian/Native American tribal governments that are not federally recognized.
Are nonprofits eligible, and is 501(c)(3) status required?
Nonprofits are eligible both with and without 501(c)(3) status (outside higher education), according to the information provided.
Are for-profit organizations eligible?
Yes. The eligibility list includes for-profit organizations (other than small businesses) and also includes small businesses as eligible applicants.
Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly highlights faith-based or community-based organizations as eligible applicant types.
Are minority-serving institutions specifically mentioned as eligible?
Yes. The FOA explicitly highlights several categories, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are U.S. territories or possessions eligible?
Yes. The eligibility list explicitly includes U.S. territories or possessions.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The eligibility list explicitly includes non-U.S. (foreign) organizations.
Are federal agencies eligible to apply?
Yes. The FOA explicitly highlights eligible federal agencies as eligible applicants.
Does the FOA indicate an interest in proposals from diverse research environments and communities?
Yes. The description notes that the wide eligibility reflects NIH interest in drawing proposals from diverse research environments and communities, including communities disproportionately affected by HIV and substance use-related harms.
What is the overall purpose of the opportunity in plain terms?
Overall, the opportunity supports foundational research to understand how HIV and substances of abuse jointly drive CNS dysfunction and to lay groundwork for new prevention or mitigation strategies for HIV-associated CNS complications in the setting of substance use disorders, without conducting clinical trials.
Browse more opportunities from the same category: Education, Health
Next opportunity: IIJA Bureau of Land Management Oregon/Washington Fisheries and Aquatic Resources Management
Previous opportunity: Chronic Kidney Disease in Children Central Biochemistry Laboratory (U24 Clinical Trial Not Allowed)
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA DA 24 013
Applicants also applied for:
Applicants who have applied for this opportunity (RFA DA 24 013) also looked into and applied for these:
| Funding Opportunity |
|---|
| Substance Use Prevention Effectiveness Research Among Youth and Families in the Child Welfare System (R61/R33 Clinical Trial Required) Apply for RFA DA 24 011 Funding Number: RFA DA 24 011 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| Substance Use Prevention Effectiveness Research Among Youth and Families in the Child Welfare System (R01 Clinical Trial Required) Apply for RFA DA 24 012 Funding Number: RFA DA 24 012 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| Development of Innovative Informatics Methods and Algorithms for Cancer Research and Management (R21 Clinical Trial Optional) Apply for RFA CA 23 014 Funding Number: RFA CA 23 014 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Advanced Development of Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional) Apply for RFA CA 23 016 Funding Number: RFA CA 23 016 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional) Apply for RFA CA 23 015 Funding Number: RFA CA 23 015 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Sustained Support for Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional) Apply for RFA CA 23 017 Funding Number: RFA CA 23 017 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Translational Centers for Microphysiological Systems (TraCe MPS) (U2C Clinical Trials Not Allowed) Apply for RFA TR 23 001 Funding Number: RFA TR 23 001 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NIDA Core "Center of Excellence" Grant Program (P30 Clinical Trial Optional) Apply for PAR 23 049 Funding Number: PAR 23 049 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Revision Applications for Validation of Biomarker Assays Developed Through NIH-Supported Research Grants (R01 Clinical Trial Not Allowed) Apply for PAR 23 088 Funding Number: PAR 23 088 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| NIDA Program Project Grant Applications (P01 Clinical Trial Optional) Apply for PAR 23 064 Funding Number: PAR 23 064 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NIDA Research Center of Excellence Grant Program (P50 Clinical Trial Optional) Apply for PAR 23 076 Funding Number: PAR 23 076 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Career Enhancement Award to Advance Research on Firearm Injury and Mortality Prevention (K18 Independent Clinical Trial Required) Apply for PAR 23 107 Funding Number: PAR 23 107 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Career Enhancement Award to Advance Research on Firearm Injury and Mortality Prevention (K18 Independent Clinical Trial Not Allowed) Apply for PAR 23 108 Funding Number: PAR 23 108 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Accelerating the Pace of Drug Abuse Research Using Existing Data (R21 Clinical Trial Optional) Apply for RFA DA 24 037 Funding Number: RFA DA 24 037 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Education Activities for Responsible Analyses of Complex, Large-Scale Data (R25- Clinical Trial Not Allowed) Apply for RFA DA 24 027 Funding Number: RFA DA 24 027 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Leveraging Big Data Science to Elucidate the Mechanisms of HIV Activity and Interaction with Substance Use Disorder (R21 Clinical Trials Not Allowed) Apply for RFA DA 24 009 Funding Number: RFA DA 24 009 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Leveraging Big Data Science to Elucidate the Mechanisms of HIV Activity and Interaction with Substance Use Disorder (R01 Clinical Trials Not Allowed) Apply for RFA DA 24 008 Funding Number: RFA DA 24 008 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| Advancing Integrated Models (AIM) of Care to Improve Pregnancy Outcomes among Women Who Experience Persistent Disparities (R01 Clinical Trial Optional) Apply for RFA NR 23 002 Funding Number: RFA NR 23 002 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Evaluating the Impact of Pandemic Era related Food and Housing Policies and Programs on Health Outcomes in Health Disparity Populations (R01 Clinical Trial Optional) Apply for RFA NR 23 003 Funding Number: RFA NR 23 003 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Clinical-Community Linkages to Address Social Needs and Social Conditions to Advance Health Equity among Populations Experiencing Health Disparities: The Bridge-to-Care Initiative (R01 Clinical Trial Required) Apply for RFA NR 23 004 Funding Number: RFA NR 23 004 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA DA 24 013", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.