Opportunity Information: Apply for RFA CA 20 030
The National Cancer Institute (NCI), part of the NIH within the U.S. Department of Health and Human Services, released this funding opportunity to build new, prospective cohort studies focused specifically on cancer survivors and the factors that shape their longer-term health. The goal is to generate actionable evidence about what drives key outcomes after cancer, including morbidity and mortality as well as quality of life and physical, social, and psychological functioning. Unlike many survivorship projects that rely on existing datasets or short follow-up windows, this announcement is aimed at creating entirely new cohorts that can fill clear gaps in current knowledge, especially in areas where survivorship science is thin or rapidly changing.
A central expectation is that each application makes a strong case for the specific scientific gap the new cohort will address. NCI highlights gaps that may be particularly compelling, such as survivorship questions arising from emerging treatments, survivorship in less common cancer types, and populations that are understudied or experience disparities in outcomes. In other words, the cohort is not meant to be a general registry or a broad descriptive effort; it should be purpose-built to answer well-justified questions where current evidence is limited, outdated, or not applicable to certain survivor groups.
The cohort design must be driven by the research questions, meaning the proposed sample size, recruitment approach, and measurement plan should all be justified based on what the study is trying to detect or explain. The announcement requires collection of information spanning five core domains: (1) disease characteristics such as cancer type and stage; (2) individual survivor characteristics such as comorbid conditions, socioeconomic status, social connections, and measures related to access to care; (3) treatment exposures, treatment-related effects, and follow-up care, including details like dose, adverse events, and palliative care; (4) behavioral and lifestyle factors such as diet and physical activity; and (5) quality of life outcomes, specifically health-related quality of life. These domains can serve as exposures or outcomes depending on the hypotheses, and the FOA encourages repeated measurements at multiple timepoints when that is appropriate for capturing change over survivorship (for example, recovery trajectories, late effects, or evolving psychosocial needs).
The award mechanism uses a two-phase cooperative agreement structure, UG3/UH3, which is designed to reduce risk and ensure feasibility before scaling to full implementation. The UG3 phase is the planning and exploratory period and is heavily focused on proving that the cohort can actually be launched: establishing recruitment pipelines, demonstrating early recruitment progress, setting up data collection systems, and showing the team can collect, manage, and begin to use the data as proposed. Importantly, recruitment does not have to be fully completed during UG3, but the investigators must show reasonable progress and provide evidence that the project will be able to meet its aims within the UH3 phase.
Transition from UG3 to UH3 depends on meeting predefined milestones. The principal investigator proposes these milestones, but they must be approved by NCI, and they need to be concrete enough to judge readiness for full implementation. Milestones are expected to include a timeline for recruitment and clear demonstrations of feasibility for data collection and analysis. The UH3 phase is the implementation phase, where the cohort enrollment and follow-up proceed at scale and the project completes the planned research agenda, using the cohort data to address the survivorship questions that motivated the study.
This is a clinical trial not allowed opportunity, meaning the research should be observational in nature rather than testing an intervention. The funding opportunity is listed as RFA-CA-20-030, using the cooperative agreement funding instrument, and it anticipates making about three awards. The award ceiling is noted as $750,000. Eligibility is broad and includes many types of organizations, such as federal-recognized tribal governments and organizations, state and local governments, public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), for-profit organizations (other than small businesses), and small businesses, among others as clarified in the full announcement. The original posting date was April 8, 2020, with an original closing date of July 7, 2020, and the CFDA listings associated with the opportunity include 93.393 and 93.399.Apply for RFA CA 20 030
- The Department of Health and Human Services, National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Utilizing Cohort Studies to Address Health Outcomes in Cancer Survivors (UG3/UH3 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.399.
- This funding opportunity was created on Apr 08, 2020.
- Applicants must submit their applications by Jul 07, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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| Strengthening Institutional Capacity to Conduct Global Cancer Research in Low- and Middle-Income Countries (D43 Clinical Trial Not Allowed) Apply for RFA CA 20 031 Funding Number: RFA CA 20 031 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| Metastasis Research Network (U54 Clinical Trial Not Allowed) Apply for RFA CA 20 029 Funding Number: RFA CA 20 029 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $1,200,000 |
| Improving Smoking Cessation Interventions among People Living with HIV (R01 Clinical Trial Optional) Apply for RFA CA 20 035 Funding Number: RFA CA 20 035 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Improving Smoking Cessation Interventions among People Living with HIV (R21 Clinical Trial Optional) Apply for RFA CA 20 036 Funding Number: RFA CA 20 036 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Emergency Awards: Exosome-based Non-traditional Technologies Towards Multi-Parametric and Integrated Approaches for SARS-CoV-2 (U18 Clinical Trial Not Allowed) Apply for RFA OD 20 018 Funding Number: RFA OD 20 018 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NLM Grants for Scholarly Works in Biomedicine and Health (G13 Clinical Trial Not Allowed) Apply for PAR 21 046 Funding Number: PAR 21 046 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $50,000 |
| Advanced Development of Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional) Apply for RFA CA 21 015 Funding Number: RFA CA 21 015 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| Sustained Support for Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional) Apply for RFA CA 21 016 Funding Number: RFA CA 21 016 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Revision Applications to Support the Application of Informatics Technology for Cancer Research (U01 Clinical Trials Optional) Apply for RFA CA 21 018 Funding Number: RFA CA 21 018 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| Development of Innovative Informatics Methods and Algorithms for Cancer Research and Management (R21 Clinical Trial Optional) Apply for RFA CA 21 013 Funding Number: RFA CA 21 013 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Revision Applications to Support the Application of Informatics Technology for Cancer Research (R01 Clinical Trials Optional) Apply for RFA CA 21 017 Funding Number: RFA CA 21 017 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| Revision Applications to Support the Application of Informatics Technology for Cancer Research (U24 Clinical Trial Optional) Apply for RFA CA 21 019 Funding Number: RFA CA 21 019 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| NIDA Translational Avant-Garde Award for Development of Medication to Treat Substance Use Disorders (UG3/UH3 Clinical Trial Optional) Apply for PAR 21 092 Funding Number: PAR 21 092 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
| HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR): Coordination and Dissemination Center (R24 Clinical Trial Optional) Apply for RFA DA 21 029 Funding Number: RFA DA 21 029 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $575,000 |
| Limited Competition to Convert the CNS HIV Antiretroviral Therapy Effects Research (CHARTER) Study Cohort to a Research Resource (R24 - Clinical Trial Not Allowed) Apply for RFA MH 21 170 Funding Number: RFA MH 21 170 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $1,250,000 |
| Proteogenomic Data Analysis Centers (PGDACs) for Clinical Proteomic Tumor Analysis Consortium (U24 Clinical Trial Not Allowed) Apply for RFA CA 21 024 Funding Number: RFA CA 21 024 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $550,000 |
| Proteogenomic Translational Research Centers (PTRCs) for Clinical Proteomic Tumor Analysis Consortium (U01 Clinical Trial Not Allowed) Apply for RFA CA 21 025 Funding Number: RFA CA 21 025 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| Proteome Characterization Centers (PCCs) for Clinical Proteomic Tumor Analysis Consortium (U24 Clinical Trial Not Allowed) Apply for RFA CA 21 023 Funding Number: RFA CA 21 023 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| 3D Technologies to Accelerate HTAN Atlas Building Efforts (UH2 Clinical Trial Not Allowed) Apply for RFA CA 21 037 Funding Number: RFA CA 21 037 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| Coordinating Center for Exercise and Nutrition Interventions to Improve Cancer Treatment-Related Outcomes (ENICTO) in Cancer Survivors Consortium (U24 Clinical Trial Not Allowed) Apply for RFA CA 21 032 Funding Number: RFA CA 21 032 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $875,000 |
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